ea0086p344 | Neuroendocrinology and Pituitary | SFEBES2022
Trainer Peter
, Ferrara-Cook Christine
, Ayala Alejandro
, Luo Rosa
, Miller Stephanie
, Wang Yang
, Hernandez-Illas Martha
, Scott Struthers R.
, Betz Stephen
, Krasner Alan
CRN04894 is a potent, orally bioavailable nonpeptide that is a highly selective antagonist for melanocortin type 2 receptor (MC2R). This receptor is found exclusively in the adrenal cortex and is the primary mediator of adrenal activation. We report results from a randomized, double-blinded, placebo-controlled (6 active:3 placebo/cohort), multiple ascending dose (40, 60, and 80 mg) study in health volunteers evaluating safety, pharmacokinetics, and pharmacodynamics of oral, on...